In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy.
作者： Wan Li Bi , Linda M. Parysek , Ronald Warnick , Peter J. Stambrook
关键词: In vitro 、 Genetic enhancement 、 Cell signaling 、 Gene 、 Bystander effect 、 Virology 、 Thymidine kinase 、 Biology 、 Viral vector 、 Ganciclovir
摘要: ABSTRACT Tumor cells transduced with a retroviral vector expressing herpes virus thymidine kinase (HSV tk) gene are rendered sensitive to the antiherpetic drug, ganciclovir. The bystander effect ...
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