Nocturnal electroencephalogram registrations in type 1 (insulin-dependent) diabetic patients with hypoglycaemia

摘要: Eight Type 1 (insulin-dependent) diabetic patients with no complications were studied overnight for two consecutive and one subsequent night continuous monitoring of electroencephalogram serial hormone measurements. The aims were: 1) to evaluate the influence spontaneous insulin-induced hypoglycaemia on nocturnal sleep-patterns and, 2) counter-regulatory responses. Spontaneous occurred six nights (38%) blood glucose concentrations less than 3.0 mmol/l four 2.0 mmol/l. All experienced a nadir 1.6 (range 1.4-1.9) was analysed by new method developed this purpose in contrast traditional definition delta-, theta-, alpha- beta-activity. concentration could be correlated rank individual electroencephalogram-patterns during whole night, specific hypoglycaemic amplitude-frequency patterns assigned. Three eight showed changes at levels below (1.6-2.0) classes representing activity had peak frequencies 4 6 Hz, respectively, clearly different from patients' delta- theta-activity. not identical each patient, however, they reproducible patient. found equally all regions brain. three only separated other five their impaired glucagon Against background possibility protection glucagon, against neurophysiologic brain may considered.