Effects of homocysteine on endothelial nitric oxide production
作者： Xiaohui Zhang , Hong Li , Haoli Jin , Zachary Ebin , Sergey Brodsky
DOI: 10.1152/AJPRENAL.2000.279.4.F671
关键词: Homocysteine 、 Peroxynitrite 、 Chemistry 、 Endothelial stem cell 、 Nitrotyrosine 、 Internal medicine 、 Nitric oxide 、 Nitric oxide synthase 、 Nitric Oxide Synthase Type III 、 Endocrinology 、 Endothelium
摘要: Hyperhomocysteinemia (HHCy) is an independent and graded cardiovascular risk factor. HHCy prevalent in patients with chronic renal failure, contributing to the increased mortality rate. Controversy exists as effects of on nitric oxide (NO) production: it has been shown that both increases suppresses it. We addressed this problem by using amperometric electrochemical NO detection a porphyrinic microelectrode study responses endothelial cells incubated homocysteine (Hcy) stimulation bradykinin, calcium ionophore, or l-arginine. Twenty-four-hour preincubation Hcy (10, 20, 50 μM) resulted gradual decline responsiveness above stimuli. did not affect expression synthase (eNOS), but stimulated formation superoxide anions, judged fluorescence dichlorofluorescein, peroxynitrite, detected immunoprecipitation immunoblotting proteins modified tyr...
sci-hub.se 参考文章(47)
Sae-Yong Hong, Dong-Ho Yang, Sung-Keun Chang, Plasma Homocysteine, Vitamin B6, Vitamin B12 and Folic Acid in End-Stage Renal Disease during Low-Dose Supplementation with Folic Acid American Journal of Nephrology. ,vol. 18, pp. 367- 372 ,(1998) , 10.1159/000013378
L. A. MacMillan-Crow, J. P. Crow, J. D. Kerby, J. S. Beckman, J. A. Thompson, Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11853- 11858 ,(1996) , 10.1073/PNAS.93.21.11853
Uttam C Garg, Aviv Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Journal of Clinical Investigation. ,vol. 83, pp. 1774- 1777 ,(1989) , 10.1172/JCI114081
T. Sundqvist, T. Forslund, T. Bengtsson, K. L. Axelsson, S-nitroso-N-acetylpenicillamine reduces leukocyte adhesion to type I collagen. Inflammation. ,vol. 18, pp. 625- 631 ,(1994) , 10.1007/BF01535260
X F Niu, C W Smith, P Kubes, Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circulation Research. ,vol. 74, pp. 1133- 1140 ,(1994) , 10.1161/01.RES.74.6.1133
Gilbert R Upchurch Jr, George N Welch, Attila J Fabian, Alessio Pigazzi, John F Keaney Jr, Joseph Loscalzo, Stimulation of endothelial nitric oxide production by homocyst (e) ine Atherosclerosis. ,vol. 132, pp. 177- 185 ,(1997) , 10.1016/S0021-9150(97)00090-7
Ian M. Graham, Plasma Homocysteine as a Risk Factor for Vascular Disease JAMA. ,vol. 277, pp. 1775- 1781 ,(1997) , 10.1001/JAMA.1997.03540460039030
Kilmer S. McCully, Robert B. Wilson, Homocysteine theory of arteriosclerosis Atherosclerosis. ,vol. 22, pp. 215- 227 ,(1975) , 10.1016/0021-9150(75)90004-0
Dawn M Bell, Thomas E Johns, Larry M Lopez, Endothelial Dysfunction: Implications for Therapy of Cardiovascular Diseases Annals of Pharmacotherapy. ,vol. 32, pp. 459- 470 ,(1998) , 10.1345/APH.17084
Victor J. Dzau, Gary H. Gibbons, Michael Mann, Ruidiger Braun-Dullaeus, Future Horizons in Cardiovascular Molecular Therapeutics American Journal of Cardiology. ,vol. 80, ,(1997) , 10.1016/S0002-9149(97)00790-X