Postchemoembolisation syndrome--tumour necrosis or hepatocyte injury?

摘要: Transarterial chemoembolisation of liver tumours is typically followed by elevated body temperature and transaminase enzymes. This has often been considered to indicate successful embolisation. The present study questions whether this syndrome reflects damage tumour cells or the normal hepatic tissue. responses 256 embolisations undertaken in 145 patients subdivided into those with hepatocyte-derived (primary hepatocellular carcinoma) nonhepatocyte-derived (secondary metastases) were analysed assess relative effects necrosis hepatocytes each group. Cytolysis, measured alanine aminotransferase, was detected 85% patients, there no difference abnormalities function tests between two groups. Furthermore, cytolysis associated a higher rate postprocedure symptoms side effects, worse survival on univariate analysis. Multivariate analysis demonstrated that benefit terms from having following Cytolysis after probably due hepatocytes. Temperature changes may reflect healthy There evidence either postchemoembolisation fever an enhanced response improved long-term primary secondary cancer.