Synthesis of an amphiphilic block copolymer containing zwitterionic sulfobetaine as a novel pH-sensitive drug carrier

摘要: pH-sensitive drug carriers offer promise for tumor targeted delivery. An amphiphilic triblock copolymer, poly(e-caprolactone)-block-poly(diethylaminoethyl methacrylate)-block-poly(sulfobetaine methacrylate) (PCL–PDEA–PSBMA), was synthesized through click reaction of alkyne end-functionalized poly(sulfobetaine (polySBMA–alkyne) onto azide PCL–PDEA (PCL–PDEA–N3) and used as a carrier in the form micelles. In particular, micelles exhibited pH dependency result protonation PDEA block. A hydrophobic drug, curcumin, chosen model to investigate potential application this copolymer drug-controlled release. The results indicated that release rate curcumin-loaded at 5.0 faster than 7.4. Furthermore, pharmacokinetics vivo showed retention time blood could extend clearance curcumin delayed, compared with solution. This new PCL–PDEA–PSBMA has great anticancer carrier.