Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
作者： Babak Kaboudin , Saeed Emadi , Atefeh Hadizadeh
DOI: 10.1016/J.BIOORG.2009.05.002
关键词: Acetylcholinesterase 、 IC50 、 Chemistry 、 Biochemistry 、 Enzyme 、 Butyrylcholinesterase 、 Differential inhibition 、 Aché 、 Potency 、 Stereochemistry
摘要: Abstract The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. compounds evaluated for their acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inhibition potency through IC50 determination. selectivities the toward both enzymes determined compared in terms molecular structures.
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