Surfactant Protein D Binds to Coxiella burnetii and Results in a Decrease in Interactions with Murine Alveolar Macrophages.

摘要: Coxiella burnetii is a Gram-negative, obligate intracellular bacterium and the causative agent of Q fever. Infections are usually acquired after inhalation contaminated particles, where C. infects its cellular target cells, alveolar macrophages. Respiratory pathogens encounter C-type lectin surfactant protein D (SP-D) during course natural infection. SP-D component innate immune response in lungs other mucosal surfaces. Many Gram-negative pulmonary interact with SP-D, which can cause aggregation, bactericidal effects aid bacterial clearance. Here we show that binds to calcium-dependent manner no detectable aggregation or effects. Since interactions bacteria often alter macrophage interactions, it was determined treatment resulted significant decrease mouse model cell line MH-S indicating causes phagocytosis. The ability modulate activation by tested does not correlates measured for activation. Taken together these studies support those demonstrating limited macrophages demonstrate participate reduction phagocyte attachment