Dexamethasone effects on the hospital course of infants with bronchopulmonary dysplasia who are dependent on artificial ventilation.

摘要: A randomized double-blind placebo-controlled trial was conducted to evaluate the effects of enterally administered dexamethasone on hospital course infants with bronchopulmonary dysplasia. total 23 a birth weight less than 1500 g who were dependent artificial ventilation 3 4 weeks age received (n = 12) or saline placebo 11). Dexamethasone (0.5 mg/kg per day) given in tapering doses for 7 days followed by hydrocortisone (8 which progressively reduced 17 therapy. Infants required oxygen 8 and (P .05) more likely extubate after therapy control group (respectively 8/12 vs 3/11 infants, P .05; .12 Yates correction). The use significantly shortened median duration mechanical (4 22 days, but had no effect length therapy, hospitalization, home occurrence severity retinopathy prematurity, rate growth, mortality. No significant complications resulted from Measurements plasma levels confirmed absorption drug gastrointestinal tract (23.7 ng/mL 4.6 group, .05). administration short-term improvements pulmonary function did not ameliorate