Virtual Screening of Natural Products to Select Compounds with Potential Anticancer Activity

作者: Élida B.V.S. Cavalcanti , Mayara B. Félix , Luciana Scotti , Marcus T. Scotti

DOI: 10.2174/1871520618666181119110934

关键词:

摘要: Cancer is the main cause of death, so search for active agents to be used in therapy this disease, necessary. According studies conducted, substances derived from natural products have shown promising endeavor. To these researches, one can associate with aid computational chemistry, which increasingly gaining popularity, due possibility developing alternative strategies that could help choosing an appropriate set compounds, avoiding unnecessary expenses resources would generate unwanted substance. Thus, objective study was carry out approach several apply different methods virtual screening select potential anticancer activity. This review presents reports conducted some products, such as coumarin, quinone, tannins, alkaloids, flavonoids and terpenes.

参考文章(136)
I Okan, D Firat, A Akcakaya, B Yilmaz, A Isik, M Sahin, A new prognostic strategy for gastric carcinoma: albumin level and metastatic lymph node ratio. Minerva Chirurgica. ,vol. 69, pp. 147- 153 ,(2014)
Maria Konstantinopoulou, Anastasia Karioti, Spyros Skaltsas, Helen Skaltsa, Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. Journal of Natural Products. ,vol. 66, pp. 699- 702 ,(2003) , 10.1021/NP020472M
Talambedu Usha, Veena Pande, Sushil Kumar Middha, Pomegranate peel attenuates hyperglycemic effects of alloxan-induced diabetic rats. Excli Journal. ,vol. 13, pp. 223- 224 ,(2014) , 10.17877/DE290R-8632
Peter Honerjäger, Cardioactive substances that prolong the open state of sodium channels. Reviews of Physiology Biochemistry and Pharmacology. ,vol. 92, pp. 1- 74 ,(1982) , 10.1007/BFB0030502
Jacques Simpore, Charlemagne Gnoula, Imaël Hn Bassole, Riccardo Scifo, Bagora Bayala, Laurent Morel, Jean-Marc A Lobaccaro, Anticancer activity of essential oils and their chemical components - a review American Journal of Cancer Research. ,vol. 4, pp. 591- 607 ,(2014)
Thomas J. Schmidt, Structure-Activity Relationships of Sesquiterpene Lactones Studies in natural products chemistry. ,vol. 33, pp. 309- 392 ,(2006) , 10.1016/S1572-5995(06)80030-X
G. Cebrián-Torrejón, A. Doménech-Carbó, M.T. Scotti, A. Fournet, B. Figadère, E. Poupon, Experimental and theoretical study of possible correlation between the electrochemistry of canthin-6-one and the anti-proliferative activity against human cancer stem cells Journal of Molecular Structure. ,vol. 1102, pp. 242- 246 ,(2015) , 10.1016/J.MOLSTRUC.2015.08.042
Eigo Otsuji, Teruhisa Sonoyama, Daisuke Ichikawa, Hisashi Ikoma, Yukihito Kokuba, Hiroyuki Sasaki, Shojiro Kikuchi, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Toshiya Ochiai, Chouhei Sakakura, Takeshi Matsui, Hiroo Konishi, Latrunculin A Has a Strong Anticancer Effect in a Peritoneal Dissemination Model of Human Gastric Cancer in Mice Anticancer Research. ,vol. 29, pp. 2091- 2097 ,(2009)