Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use

摘要: Background The serum total homocysteine concentration (tHcy), an indicator of folate status and a possible risk factor for vascular disease, is elevated with impaired renal function poor vitamin B-12 status, which are common in the elderly. Objective Our objective was to determine association between tHcy, intake, alcohol consumption, other lifestyle factors elderly persons. Design This cross-sectional study used linear regression model changes tHcy. Subjects were 278 men women aged 66-94 y studied 1993. Results Total intake negatively associated tHcy models adjusted age, sex, creatinine, albumin. We found interaction food supplement use. Food had inverse dose-response relation that limited nonusers supplements. Predicted 1.5 micromol/L lower users supplements containing than independent intake. positive coffee tea > or = 60 drinks/mo compared low use Compared users, higher predicted Conclusions strongest among drinkers. Identifying modifiable related especially important