Epidermal growth factor receptor signaling.

摘要: Inhibitory signaling is an important way of fine tuning EGFR activity to enable a cell discriminate between short and prolonged exposure molecules. Over the last few years number different mechanisms have been shown abrogate receptor (Fig. 3Fig. 3). First, inhibitory molecules are expressed in response activation. The most prominent example encoded by Drosophila gene argos. Argos secreted molecule that has single EGF-like domain with expanded B-loop. Binding experiments showed binds directly presumably via its inhibits activity. prevents Spitz binding may also interfere ligand-independent activation preventing formation active dimers.Fig. 3Negative regulators signaling. Several proteins were found attenuate Argos, Decorin, Kekkon bind extracellular EGFR. PKC able phosphorylate at T654. Cbl Y1045 results ubiquitination subsequent degradation. recently identified Echinoid protein interferes downstream. LRR, leucine-rich repeat; Ig, immunoglobulin-like domain; FnIII, fibronectin type III repeat.View Large Image | View Hi-Res Download PowerPoint SlideBesides other Again powerful system for identifying new components which can inhibit Kekkon, activity, encodes I transmembrane resembles adhesion provides mechanism negative-feedback. Two additional Kekkon-like genome await characterisation.The shows identity L1 defines pathway antagonizing downstream receptor. be influenced matrix. One proteoglycan Decorin phosphorylation.sprouty cbl genes encode global inhibitors Sprouty contains conserved cysteine-rich associates cascade such as Grb2/Drk GAP1. function is, however, not restricted pathway. unusual SH2 responsible Y1045. This interaction leads phosphorylation Cbl, facilitate ubiquitin ligase RING finger domain. Ubiquitination internalization clathrin-coated vesicles degradation.In summary, appears integrated complex regulatory network linking signals cytoplasm nucleus. In decade modulation negative become more evident. Now picture getting even complicated fact differential trafficking activated lead cellular responses. Further studies only help increase our understanding role developing animal, they ultimately development efficient anti-cancer therapeutics.