Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation

摘要: CD22 is an inhibitory coreceptor on the surface of B cells that attenuates cell antigen receptor (BCR) signaling and, therefore, activation. Elucidating molecular mechanisms underlying activity complicated by ubiquity ligands. Although antigens can display ligands, known to bind sialylated glycoproteins surface. The propinquity and cell-surface glycoprotein ligands has led conclusion properties are due cis interactions. Here, we examine functional consequences trans interactions employing multivalent engage both BCR. Exposure results in inhibition key steps BCR signaling. These reveal bearing powerful suppressors ability inhibit through reveals a previously unrecognized role for Siglec-family receptors as modulators immune