Epigenetic reprogramming in cancer
作者： Anders M. Lindroth , Yoon Jung Park , Christoph Plass
DOI: 10.1007/978-3-642-31974-7_9
关键词:
摘要: Cancer is by and large caused a combination of genetic lesions obstructed gene expression patterns that put afflicted cells in growth advantage. Recent research has shown DNA methylation, histone modifications, chromatin remodeling, noncoding RNA have profound influence on tumorigenesis. The epigenetic modifications act concert, sometimes antagonistically, manage to orchestrate the pattern making more or less accessible transcription factors other DNA-binding proteins. Here, we review components directly influencing structure normal parallel with ones been implicated driving initiating processes leading pluripotency from terminally differentiated state show similarities pathogenesis neoplasia, highlight some recent findings patterning remodeling instrumental formation cancer stem tumor-initiating cells.
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