Spread of MHV-JHM from nasal cavity to white matter of spinal cord. Transneuronal movement and involvement of astrocytes.
作者： S. Perlman , N. Sun , E. M. Barnett
DOI: 10.1007/978-1-4615-1899-0_10
关键词:
摘要: C57B1/6 mice infected intranasally with mouse hepatitis virus, strain JHM (MHV-JHM) develop hindlimb paralysis histological evidence of demyelination several weeks after inoculation. Virus must spread from the site inoculation, nasal cavity, to disease, white matter spinal cord. It has been shown previously that intranasal virus enters brain via olfactory nerve and spreads infect many its neuroanatomic connections within central nervous system (CNS). In this report, it is infecting cord first detected in gray matter, occurring soon thereafter. Astrocytes are heavily during process Since astrocytes intimate contact neuronal synapses themselves connected gap junctions, these results suggest may be a conduit for mice. provide factors proliferation survival oligodendrocytes, widespread infection cells might contribute demyelinating eventually observed Additionally, since appears at specific locations cord, should possible determine source While not definitive, data most consistent spreading ventral reticular formation cervical
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