Polymerase Switching in Response to DNA Damage

摘要: DNA polymerases are highly efficient and accurate macromolecular machines. They capable of replicating at up to 1,000 nucleotides per second while making less than one error in 100,000 additions. However, is constantly subjected damage from myriad sources. disrupts normal cellular replication by interfering with the accuracy efficiency replicative polymerases. Specialized Y family exist that can copy damaged DNA, although ability often has a mutagenic cost. Therefore, polymerase activity regulated cell. This chapter presents functions both mechanisms management. The focus on Escherichia coli systems but also briefly discusses eukaryotic We first present carried out prokaryotic III describe its subunits coordination leading lagging strand replication. then discuss specialized Different models for management presented. Finally, we compare their counterparts.