Future prospects in the treatment of lupus nephritis: proliferative lupus nephritis

摘要: Lupus nephritis is a common manifestation of systemic lupus erythematosus, and predictor an adverse outcome in this disease. With respect to long-term renal outcome, cyclophosphamide pulses plus steroids are the standard therapy for nephritis. During last decade, first international, multicenter, randomized controlled trials were conducted evaluate new substances treatment The testing other immunosuppressive drugs, anticellular therapies, modulation cell–cell interactions, (anti)cytokine therapies erythematosus-specific immunomodulation currently underway. On basis experiences from indications, mycophenolate rituximab most promising concluding 30 years without any licensed drugs. Other approaches appear use more specific interventions, but it may be that evaluation anticytokine interventions or requires biomarkers enable a...