Regulation of NF-κB signaling by ASK1 through interaction with NIK
作者： In-Seon Lee , Hee-Yun Seo , Sa-Yeon Cho
DOI: 10.5012/BKCS.2010.31.7.2110
关键词:
摘要: (A) Overexpressed NIK and ASK1proteins bind directly. HA-tagged ASK1 FLAG-NIK were tran-siently co-transfected into BOSC 23 cells, the lysates immuno-precipitated with appropriate antibodies. Samples subjected to Western blotting analysis using The expressionof transfected plasmids indicated in same lysates. IP, immuno-precipitation; IB, immunoblot. (B) binds C-terminal domai nof ASK1. cells transiently FLAG-tagged wild-type or mutant expression plasmids. Transfected extracted immunoprecipitated an anti-HA antibody. interaction was detected by anti-FLAG
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