Effective homocysteine metabolism may protect South African blacks against coronary heart disease

摘要: L-Methionine (0.1 g/kg body wt) was administered to young white [n = 18; mean (+/- SD) age 20.0 +/- 1.0 y] and black 12; 22.0 1.3 volunteers who had a similar lifestyle did not differ significantly from each other with respect plasma folate or vitamin B-12 concentrations. Blacks, however, lower pyridoxal-5'-phosphate concentrations compared whites (P < 0.001). Fasting homocysteine in blacks were different. The maximum increase concentration measured after methionine loading 0.01) (11.0 3.6 mumol/L) than (18.0 6.2 mumol/L). Six weeks of supplementation (1.0 mg folic acid, 400 micrograms B-12, 10 pyridoxine/d) reduced the fasting 9.6 3.5 7.2 1.6 mumol/L 0.05) 8.4 2.4 5.6 1.4 0.01). declined 18.0 11.1 2.3 whites, but have significant effect on methionine-load test volunteers. A race-by-time interaction shows that metabolized more effectively which may partly explain their relative resistance against coronary heart disease despite high prevalence obesity, hypertension, smoking.