Key references: pathology/physiology including thrombosis.

I. Nyman, H. Larsson, Lars Wallentin, Prevention of serious cardiac events by low-dose aspirin in patients with silent myocardial ischaemia The Lancet. ,vol. 340, pp. 497- 501 ,(1992) , 10.1016/0140-6736(92)91706-E

Paul M Ridker, Patricia R Hebert, CH Hennekens, V Fuster, None, Are both aspirin and heparin justified as adjuncts to thrombolytic therapy for acute myocardial infarction The Lancet. ,vol. 341, pp. 1574- 1578 ,(1993) , 10.1016/0140-6736(93)90707-N

Diana Holdright, Deven Patel, David Cunningham, Roderic Thomas, William Hubbard, Gordon Hendry, George Sutton, Kim Fox, Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina Journal of the American College of Cardiology. ,vol. 24, pp. 39- 45 ,(1994) , 10.1016/0735-1097(94)90539-8

M Sobel, E W Salzman, G C Davies, R I Handin, J Sweeney, J Ploetz, G Kurland, Circulating platelet products in unstable angina pectoris. Circulation. ,vol. 63, pp. 300- 306 ,(1981) , 10.1161/01.CIR.63.2.300

H. D. White, P. E. Aylward, M. J. Frey, A. A. J. Adgey, R. Nair, W. S. Hillis, Y. Shalev, M. A. Brown, J. K. French, R. Collins, J. Maraganore, B. Adelman, Randomized, Double-blind Comparison of Hirulog Versus Heparin in Patients Receiving Streptokinase and Aspirin for Acute Myocardial Infarction (HERO) Circulation. ,vol. 96, pp. 2155- 2161 ,(1997) , 10.1161/01.CIR.96.7.2155

Eric J Topol, Randomised placebo-controlled and balloon-angioplasty- controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade The Lancet. ,vol. 352, pp. 87- 92 ,(1998) , 10.1016/S0140-6736(98)85010-1

Paul W. Armstrong, Heparin in Acute Coronary Disease — Requiem for a Heavyweight? The New England Journal of Medicine. ,vol. 337, pp. 492- 494 ,(1997) , 10.1056/NEJM199708143370710

Eric J. Topol, Evolution of improved antithrombotic and antiplatelet agents: genesis of the Comparison of Abciximab Complications with Hirulog [and back-Up Abciximab] Events Trial (CACHET). American Journal of Cardiology. ,vol. 82, ,(1998) , 10.1016/S0002-9149(98)00664-X

Charles L Bennett, Peter D Weinberg, Karine Rozenberg-Ben-Dror, Paul R Yarnold, Hau C Kwaan, David Green, Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine: A Review of 60 Cases Annals of Internal Medicine. ,vol. 128, pp. 541- 544 ,(1998) , 10.7326/0003-4819-128-7-199804010-00004

KimM. Fox, Anne Jonathan, AndrewP. Selwyn, Effects of platelet inhibition on myocardial ischaemia. The Lancet. ,vol. 320, pp. 727- 730 ,(1982) , 10.1016/S0140-6736(82)90919-9