Strategies for the enantioselective synthesis of spirooxindoles.

摘要: Oxindoles and spirooxindoles are important synthetic targets that often considered to be prevalidated with respect their biological activity applications for pharmaceutical lead discovery. This review features efficient strategies the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 2011. Although remains an ongoing challenge, exciting recent advances this area feature greater complexity, up eight stereogenic centers, more practical methods, new catalytic activation strategies. Developments catalyst systems reaction conditions have shown many reactions can optimized control selectivity provide access isomeric products, which testing. is organized based two primary disconnection strategies, then further subdivided into type ring size spirocycle generated. Strategies also compared non-spirocyclic 3,3′-disubstituted oxindoles.