Enhanced erythropoiesis induced by hypoxia in hypertransfused, post-hypoxic mice.

摘要: The erythropoietic response, measured as RBC-59Fe uptake after 24 h-exposure to hypoxia, were determined in posthypoxic, "acute" and "chronic" hypertransfused, posthypoxic-hypertransfused mice. Radioiron by erythrocytes was about 25 times greater post-hypoxic than both types of hypertransfused Posthypoxic-hypertransfused mice showed an response hypoxia which not significantly different from that posthypoxic 20 those When exposed before transfusions, a linear increase 59Fe values observed with exposures between 6 30 h. No further for 46 216 These results suggest sensitization the erythropoietin-producing organ(s) hypoxia.