Intermittent parathyroid hormone 1-34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone.
作者： Yohsuke Yoshioka , Eiki Yamachika , Makoto Nakanishi , Tadashi Ninomiya , Sho Akashi
DOI: 10.1038/S41598-019-44389-8
关键词:
摘要: Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on mineral collagen quality jaw are not well understood. Most studies have focused analyzing density microstructure mandible, insufficiently investigated its quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, worsens We hypothesized that induces oxidation affects newly formed mandibular bone. To test this, we examined in rats administered PTH, analyzed serum intermittent examine degree oxidation. reduced mineralization worsened In addition, total anti-oxidant capacity was significantly decreased oxidative-INDEX increased among PTH-treated compared vehicle-treated rats, indicating conclusion, This effect may been induced by
harvard.edu
okayama-u.ac.jp
nature.com
elsevier.com
sci-hub.se 参考文章(35)
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, Osteoporosis Prevention, Diagnosis, and Therapy JAMA: The Journal of the American Medical Association. ,vol. 285, pp. 785- 795 ,(2001) , 10.1001/JAMA.285.6.785
Anson C M Chau, Frederick C S Chu, John Chai, Tak W Chow, Correlation between dental implant insertion torque and mandibular alveolar bone density in osteopenic and osteoporotic subjects. International Journal of Oral & Maxillofacial Implants. ,vol. 27, pp. 888- 893 ,(2012)
Shinichiro Kuroshima, Munenori Yasutake, Kotaro Tsuiki, Takayoshi Nakano, Takashi Sawase, Structural and Qualitative Bone Remodeling Around Repetitive Loaded Implants in Rabbits. Clinical Implant Dentistry and Related Research. ,vol. 17, ,(2015) , 10.1111/CID.12318
Veronica Kei Len Chin, Adriana Shinagawa, Maria da Graca Naclerio-Homem, Bone healing of mandibular critical-size defects in spontaneously hypertensive rats. Brazilian Oral Research. ,vol. 27, pp. 423- 430 ,(2013) , 10.1590/S1806-83242013000500006
Michael D. Morris, Gurjit S. Mandair, Raman assessment of bone quality. Clinical Orthopaedics and Related Research. ,vol. 469, pp. 2160- 2169 ,(2011) , 10.1007/S11999-010-1692-Y
R. Reiter, Regina Carneiro, C.-S. Oh, Melatonin in Relation to Cellular Antioxidative Defense Mechanisms Hormone and Metabolic Research. ,vol. 29, pp. 363- 372 ,(1997) , 10.1055/S-2007-979057
Fong-Fu Chou, Chiang-Hsuan Lee, Jin-Bor Chen, Shun-Chen Huang, Chien-Te Lee, Sleep disturbances before and after parathyroidectomy for secondary hyperparathyroidism Surgery. ,vol. 137, pp. 426- 430 ,(2005) , 10.1016/J.SURG.2004.12.010
David G. Quintero, Julia N. Winger, Rania Khashaba, James L. Borke, Advanced Glycation Endproducts and Rat Dental Implant Osseointegration Journal of Oral Implantology. ,vol. 36, pp. 97- 103 ,(2010) , 10.1563/AAID-JOI-D-09-00032
Eve Donnelly, Dan X. Chen, Adele L. Boskey, Shefford P. Baker, Marjolein C. H. van der Meulen, Contribution of Mineral to Bone Structural Behavior and Tissue Mechanical Properties Calcified Tissue International. ,vol. 87, pp. 450- 460 ,(2010) , 10.1007/S00223-010-9404-X
Troels T. Andreassen, Charlotte Ejersted, Hans Oxlund, Intermittent Parathyroid Hormone (1–34) Treatment Increases Callus Formation and Mechanical Strength of Healing Rat Fractures Journal of Bone and Mineral Research. ,vol. 14, pp. 960- 968 ,(1999) , 10.1359/JBMR.1999.14.6.960