Substituted quinazoline derivatives and their use as tyrosine kinase inhibitors

摘要: This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed 1. R2 various unsaturated acyl with certain being disclaimed. Use tyrosine kinase inhibitors for treatment cancer kidney diseases such polycystic disease.