Eye Lens Crystallins: Remarkable Long‐Lived Proteins

Yi Zhai, Jinyu Li, Wangshu Yu, Sha Zhu, Yinhui Yu, Menghan Wu, Guizhen Sun, Xiaohua Gong, Ke Yao, Targeted Exome Sequencing of Congenital Cataracts Related Genes: Broadening the Mutation Spectrum and Genotype–Phenotype Correlations in 27 Chinese Han Families Scientific Reports. ,vol. 7, pp. 1219- ,(2017) , 10.1038/S41598-017-01182-9

Tianqi O. Zhang, Ariel M. Alperstein, Martin T. Zanni, Amyloid β-Sheet Secondary Structure Identified in UV-Induced Cataracts of Porcine Lenses using 2D IR Spectroscopy. Journal of Molecular Biology. ,vol. 429, pp. 1705- 1721 ,(2017) , 10.1016/J.JMB.2017.04.014

Miduturu Srinivas, Vytas K. Verselis, Thomas W. White, Human diseases associated with connexin mutations Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 1860, pp. 192- 201 ,(2018) , 10.1016/J.BBAMEM.2017.04.024

Jennifer C. Boatz, Matthew J. Whitley, Mingyue Li, Angela M. Gronenborn, Patrick C. A. van der Wel, Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH. Nature Communications. ,vol. 8, pp. 15137- ,(2017) , 10.1038/NCOMMS15137

Nicholas J. Ray, Damien Hall, John A. Carver, A structural and functional study of Gln147 deamidation in αA-crystallin, a site of modification in human cataract. Experimental Eye Research. ,vol. 161, pp. 163- 173 ,(2017) , 10.1016/J.EXER.2017.05.005

Wei-Jie Zhao, Jia Xu, Xiang-Jun Chen, Hui-Hui Liu, Ke Yao, Yong-Bin Yan, Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding International Journal of Biological Macromolecules. ,vol. 103, pp. 764- 770 ,(2017) , 10.1016/J.IJBIOMAC.2017.05.109

Lothar Gremer, Daniel Schölzel, Carla Schenk, Elke Reinartz, Jörg Labahn, Raimond B. G. Ravelli, Markus Tusche, Carmen Lopez-Iglesias, Wolfgang Hoyer, Henrike Heise, Dieter Willbold, Gunnar F. Schröder, Fibril structure of amyloid-β(1–42) by cryo–electron microscopy Science. ,vol. 358, pp. 116- 119 ,(2017) , 10.1126/SCIENCE.AAO2825

Patrick C.A. van der Wel, Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy. Solid State Nuclear Magnetic Resonance. ,vol. 88, pp. 1- 14 ,(2017) , 10.1016/J.SSNMR.2017.10.001

Ruifang Sui, Qi Zhou, Lizhu Yang, Zixi Sun, Shijing Wu, Huajin Li, Mutations in crystallin genes result in congenital cataract associated with other ocular abnormalities Molecular Vision. ,vol. 23, pp. 977- 986 ,(2017)

John A. Carver, Heath Ecroyd, Roger J. W. Truscott, David C. Thorn, Carl Holt, Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins Accounts of Chemical Research. ,vol. 51, pp. 745- 752 ,(2018) , 10.1021/ACS.ACCOUNTS.7B00250