Effects of BHA, d-α-tocopherol and retinol acetate on TCDD-mediated changes in lipid peroxidation, glutathione peroxidase activity and survival
作者： S. J. Stohs , M. Q. Hassan , W. J. Murray
DOI: 10.3109/00498258409151443
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摘要: 1. Daily treatment of female rats with butylated hydroxyanisole (BHA) protected against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity. This protective effect was associated reduced microsomal lipid peroxidation, increased glutathione peroxidase (GSH-PX) activity and decreased aryl hydrocarbon hydroxylase (AHH) activity.2. Retinol acetate (vitamin A) inhibited elevated GSH-PX activity, enhanced AHH activity. Thirty per cent vitamin A-treated animals were alive 25 d after a lethal dose TCDD.3. d-α-Tocopherol E) markedly had no on Only 10% the E-treated TCDD.4. The mechanism TCDD toxicity may involve in part inhibition resultant peroxidation by hydrogen peroxide.
informahealthcare.com参考文章(17)
M. A. Cawthorne, J. Bunyan, M. V Sennitt, J Green, P. Grasso, Vitamin E and hepatotoxic agents: 3.* Vitamin E, synthetic antioxidants and carbon tetrachloride toxicity in the rat British Journal of Nutrition. ,vol. 24, pp. 357- 384 ,(1970) , 10.1079/BJN19700038
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Francis J. Peterson, Gerald F. Combs, Jordan L. Holtzman, Ronald P. Mason, Effect of Selenium and Vitamin E Deficiency on Nitrofurantoin Toxicity in the Chick Journal of Nutrition. ,vol. 112, pp. 1741- 1746 ,(1982) , 10.1093/JN/112.9.1741
Young H Lee, Donald K Layman, Roma R Bell, None, Glutathione peroxidase activity in iron-deficient rats. Journal of Nutrition. ,vol. 111, pp. 194- 200 ,(1981) , 10.1093/JN/111.1.194
R. A. Neal, J. R. Olson, T. A. Gasiewicz, L. E. Geiger, The Toxicokinetics of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin in Mammalian Systems Drug Metabolism Reviews. ,vol. 13, pp. 355- 385 ,(1982) , 10.3109/03602538209029985
J.E. Kinsella, Increased lipoperoxide content of orotic acid-induced fatty liver. Biochimica et Biophysica Acta. ,vol. 137, pp. 205- 207 ,(1967) , 10.1016/0005-2760(67)90031-8
M. Q. Hassan, S. J. Stohs, W. J. Murray, Comparative ability of TCDD to induce lipid peroxidation in rats, guinea pigs, and Syrian golden hamsters. Bulletin of Environmental Contamination and Toxicology. ,vol. 31, pp. 649- 657 ,(1983) , 10.1007/BF01606041
Fumio Matsumura, Biochemical aspects of action mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals in animals. Pharmacology & Therapeutics. ,vol. 19, pp. 195- 209 ,(1982) , 10.1016/0163-7258(82)90062-6
R. J. Kociba, B. A. Schwetz, Toxicity of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) Drug Metabolism Reviews. ,vol. 13, pp. 387- 406 ,(1982) , 10.3109/03602538209029986
S.J. Stohs, M.Q. Hassan, W.J. Murray, Lipid peroxidation as a possible cause of TCDD toxicity Biochemical and Biophysical Research Communications. ,vol. 111, pp. 854- 859 ,(1983) , 10.1016/0006-291X(83)91377-3