An overview of cannabis based treatment in Crohn's disease.
作者： Timna Naftali
DOI: 10.1080/17474124.2020.1740590
关键词:
摘要: Introduction: Cannabis use among inflammatory bowel disease (IBD) patients is common. There are many studies of various laboratory models demonstrating the anti-inflammatory effect cannabis, but their translation to human still lacking.Areas covered: The cannabis plant contains cannabinoids, that activate endocannabinoid system. two most abundant phytocannabinoids psychoactive Tetrahydrocannabinol (THC), and (mostly) cannabidiol (CBD). Approximately 15% IBD ameliorate symptoms. Unfortunately, so far there only three small placebo controlled study regarding in active Crohns disease, combining altogether 93 subjects. Two showed significant clinical improvement no markers inflammation.Expert opinion: seems have a therapeutic potential IBD. This must not be neglected; however, research at very early stage. complexity diversity different chemovars create an inherent difficulty research. We need more investigating compounds. These effects can then investigated randomized trials fully explore treatment
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