Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: a meta-analysis.
作者： XIWEN WANG , HUAPING XIAO , HAIBING LAN , CHEN MAO , QING CHEN
DOI: 10.1111/J.1440-1843.2011.01976.X
关键词:
摘要: Background and objective: Genetic background may influence susceptibility pulmonary tuberculosis. The evidence for an association between the P2X7 receptor A1513C polymorphism to tuberculosis remains inconclusive. In order provide a more precise estimate of this association, meta-analysis was performed. Methods: Databases, including PUBMED, OVID, ScienceDirect, SpringerLink, EBSCO EMBASE were searched publications that met inclusion criteria. A fixed effect model used pooled OR with 95% CI polymorphism. chi-squared-based Q-test test heterogeneity hypothesis. Begg's Egger's check publication bias. Results: Six published case–control studies investigated in 2525 subjects included meta-analysis. hypothesis did not reveal any heterogeneity. detect obvious bias among studies. This indicated there no significant (AC vs AA model: 1.12, CI: 0.93–1.35; CC 1.45, 0.92–2.28; AC + 1.15, 0.96–1.13; 1.42, 0.90–2.23). Conclusions: six involving suggested A1531C is associated
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