The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse
作者： Matthew Bjerknes , Hazel Cheng
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摘要: In the first two articles of this series we demonstrated restriction of Paneth cell formation to positions 5 and above. Restriction was independent of the Paneth cell population‐density gradient in the crypt base. We concluded that our results were consistent with the presence in the adult of a stem‐cell zone in positions 1–4 in which stem cells received no inducement to differentiate. To further test the stem‐cell zone hypothesis we determined the site of stem‐cell differentiation along mucous, enteroendocrine, and columnar cell lines using …
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