Use of activated charcoal to reduce elevated serum phenobarbital concentration in a neonate

摘要: The course of a neonate administered activated charcoal orally for elevated phenobarbital concentration is described. required serum eventually exceeding 80 micrograms/mL seizure control. However, due to the severe CNS injury as result asphyxia at birth, diagnosis cerebral death by electroencephalogram and apnea test was pursued. This be less than 30 micrograms/mL. Serial concentrations during this time indicated 250 hour half-life, which would require two weeks drop below With administration six doses 0.7 g/kg/dose, decreased 22 micrograms/mL, giving an estimated half-life hours. This, other subsequent cases, indicates repeated are effective in augmenting clearance certain drugs neonatal age group.