Translating genomic discoveries to the clinic in pediatric oncology.

Nigel J. O’Neil, Derek M. van Pel, Philip Hieter, Synthetic lethality and cancer: cohesin and PARP at the replication fork. Trends in Genetics. ,vol. 29, pp. 290- 297 ,(2013) , 10.1016/J.TIG.2012.12.004

Tobias Rausch, David T.W. Jones, Marc Zapatka, Adrian M. Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A. Northcott, Elke Pfaff, Jelena Tica, Qi Wang, Luca Massimi, Hendrik Witt, Sebastian Bender, Sabrina Pleier, Huriye Cin, Cynthia Hawkins, Christian Beck, Andreas von Deimling, Volkmar Hans, Benedikt Brors, Roland Eils, Wolfram Scheurlen, Jonathon Blake, Vladimir Benes, Andreas E. Kulozik, Olaf Witt, Dianna Martin, Cindy Zhang, Rinnat Porat, Diana M. Merino, Jonathan Wasserman, Nada Jabado, Adam Fontebasso, Lars Bullinger, Frank G. Rücker, Konstanze Döhner, Hartmut Döhner, Jan Koster, Jan J. Molenaar, Rogier Versteeg, Marcel Kool, Uri Tabori, David Malkin, Andrey Korshunov, Michael D. Taylor, Peter Lichter, Stefan M. Pfister, Jan O. Korbel, Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations Cell. ,vol. 148, pp. 59- 71 ,(2012) , 10.1016/J.CELL.2011.12.013

Robert Huether, Li Dong, Xiang Chen, Gang Wu, Matthew Parker, Lei Wei, Jing Ma, Michael N Edmonson, Erin K Hedlund, Michael C Rusch, Sheila A Shurtleff, Heather L Mulder, Kristy Boggs, Bhavin Vadordaria, Jinjun Cheng, Donald Yergeau, Guangchun Song, Jared Becksfort, Gordon Lemmon, Catherine Weber, Zhongling Cai, Jinjun Dang, Michael Walsh, Amanda L Gedman, Zachary Faber, John Easton, Tanja Gruber, Richard W Kriwacki, Janet F Partridge, Li Ding, Richard K Wilson, Elaine R Mardis, Charles G Mullighan, Richard J Gilbertson, Suzanne J Baker, Gerard Zambetti, David W Ellison, Jinghui Zhang, James R Downing, None, The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes Nature Communications. ,vol. 5, pp. 3630- 3630 ,(2014) , 10.1038/NCOMMS4630

Gail P Jarvik, Laura M Amendola, Jonathan S Berg, Kyle Brothers, Ellen W Clayton, Wendy Chung, Barbara J Evans, James P Evans, Stephanie M Fullerton, Carlos J Gallego, Garrison Nanibaa’A, Stacy W Gray, Ingrid A Holm, Iftikhar J Kullo, Lisa Soleymani Lehmann, Cathy McCarty, Cynthia A Prows, Heidi L Rehm, Richard R Sharp, Joseph Salama, Saskia Sanderson, Sara L Van Driest, Marc S Williams, Susan M Wolf, Wendy A Wolf, John Harley, Melanie Myers, Bahram Namjou, Sander Vinks, John Connolly, Brendan Keating, Glenn Gerhard, Agnes Sundaresan, Gerard Tromp, David Crosslin, Kathy Leppig, Cathy Wicklund, Christopher Chute, John Lynch, Mariza De Andrade, John Heit, Jen McCormick, Murray Brilliant, Terrie Kitchner, Marylyn Ritchie, Erwin Böttinger, Inga Peter, Stephen Persell, Laura Rasmussen-Torvik, Tracy McGregor, Dan Roden, Armand Antommaria, Rosetta Chiavacci, Andy Faucett, David Ledbetter, Janet Williams, Andrea Hartzler, Carolyn R Rohrer Vitek, Norm Frost, Kadija Ferryman, Carol Horowitz, Rosamond Rhodes, Randi Zinberg, Sharon Aufox, Vivian Pan, Rochelle Long, Erin Ramos, Jackie Odgis, Anastasia Wise, Sara Hull, Jonathan Gitlin, Robert Green, Danielle Metterville, Amy McGuire, Sek Won Kong, Sue Trinidad, David Veenstra, Myra Roche, Debra Skinner, Kelly Raspberry, Julianne O’Daniel, Will Parsons, Christine Eng, Susan Hilsenbeck, Dean Karavite, Laura Conlin, Nancy Spinner, Ian Krantz, Marni Falk, Avni Santani, Elizabeth Dechene, Matthew Dulik, Barbara Bernhardt, Scott Schuetze, Jessica Everett, Michele Caroline Gornick, Ben Wilfond, Holly Tabor, Amy A Lemke, Sue Richards, Katrina Goddard, Greg Cooper, Kelly East, Greg Barsh, Barbara Koenig, Eliezer Van Allen, Judy Garber, Jeremy Garrett, Michelle Lewis, Sarah Savage, Maureen Smith, Sameek Roychowdhury, Alice Bailey, Benjamin Berkman, Charlisse Caga Anan, Lucia Hindorff, Carolyn Hutter, Rosalind King, Rongling Li, Nicole Lockhart, Jean McEwen, Derek Scholes, Sheri Schully, Kathie Sun, Wylie Burke, None, Return of Genomic Results to Research Participants: The Floor, the Ceiling, and the Choices In Between American Journal of Human Genetics. ,vol. 94, pp. 818- 826 ,(2014) , 10.1016/J.AJHG.2014.04.009

James R Downing, Richard K Wilson, Jinghui Zhang, Elaine R Mardis, Ching-Hon Pui, Li Ding, Timothy J Ley, William E Evans, None, The Pediatric Cancer Genome Project Nature Genetics. ,vol. 44, pp. 619- 622 ,(2012) , 10.1038/NG.2287

Giles Robinson, Matthew Parker, Tanya A. Kranenburg, Charles Lu, Xiang Chen, Li Ding, Timothy N. Phoenix, Erin Hedlund, Lei Wei, Xiaoyan Zhu, Nader Chalhoub, Suzanne J. Baker, Robert Huether, Richard Kriwacki, Natasha Curley, Radhika Thiruvenkatam, Jianmin Wang, Gang Wu, Michael Rusch, Xin Hong, Jared Becksfort, Pankaj Gupta, Jing Ma, John Easton, Bhavin Vadodaria, Arzu Onar-Thomas, Tong Lin, Shaoyi Li, Stanley Pounds, Steven Paugh, David Zhao, Daisuke Kawauchi, Martine F. Roussel, David Finkelstein, David W. Ellison, Ching C. Lau, Eric Bouffet, Tim Hassall, Sridharan Gururangan, Richard Cohn, Robert S. Fulton, Lucinda L. Fulton, David J. Dooling, Kerri Ochoa, Amar Gajjar, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Jinghui Zhang, Richard J. Gilbertson, Novel mutations target distinct subgroups of medulloblastoma Nature. ,vol. 488, pp. 43- 48 ,(2012) , 10.1038/NATURE11213

Julia L. Glade Bender, Alice Lee, Joel M. Reid, Sylvain Baruchel, Timothy Roberts, Stephan D. Voss, Bing Wu, Charlotte H. Ahern, Ashish M. Ingle, Pamela Harris, Brenda J. Weigel, Susan M. Blaney, Phase I Pharmacokinetic and Pharmacodynamic Study of Pazopanib in Children With Soft Tissue Sarcoma and Other Refractory Solid Tumors: A Children’s Oncology Group Phase I Consortium Report Journal of Clinical Oncology. ,vol. 31, pp. 3034- 3043 ,(2013) , 10.1200/JCO.2012.47.0914

Matthew Parker, Kumarasamypet M Mohankumar, Chandanamali Punchihewa, Ricardo Weinlich, James D Dalton, Yongjin Li, Ryan Lee, Ruth G Tatevossian, Timothy N Phoenix, Radhika Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, Kirti Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatte, Erin Hedlund, David Finkelstein, Gang Wu, Sheila Shurtleff, John Easton, Kristy Boggs, Donald Yergeau, Bhavin Vadodaria, Heather L Mulder, Jared Becksfort, Pankaj Gupta, Robert Huether, Jing Ma, Guangchun Song, Amar Gajjar, Thomas Merchant, Frederick Boop, Amy A Smith, Li Ding, Charles Lu, Kerri Ochoa, David Zhao, Robert S Fulton, Lucinda L Fulton, Elaine R Mardis, Richard K Wilson, James R Downing, Douglas R Green, Jinghui Zhang, David W Ellison, Richard J Gilbertson, None, C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma Nature. ,vol. 506, pp. 451- 455 ,(2014) , 10.1038/NATURE13109

Nada Jabado, Mark W Kieran, Adam M Fontebasso, Simon Papillon-Cavanagh, Jeremy Schwartzentruber, Hamid Nikbakht, Noha Gerges, Pierre-Olivier Fiset, Denise Bechet, Damien Faury, Nicolas De Jay, Lori A Ramkissoon, Aoife Corcoran, David T W Jones, Dominik Sturm, Pascal Johann, Tadanori Tomita, Stewart Goldman, Mahmoud Nagib, Anne Bendel, Liliana Goumnerova, Daniel C Bowers, Jeffrey R Leonard, Joshua B Rubin, Tord Alden, Samuel Browd, J Russell Geyer, Sarah Leary, George Jallo, Kenneth Cohen, Nalin Gupta, Michael D Prados, Anne-Sophie Carret, Benjamin Ellezam, Louis Crevier, Almos Klekner, Laszlo Bognar, Peter Hauser, Miklos Garami, John Myseros, Zhifeng Dong, Peter M Siegel, Hayley Malkin, Azra H Ligon, Steffen Albrecht, Stefan M Pfister, Keith L Ligon, Jacek Majewski, Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma Nature Genetics. ,vol. 46, pp. 462- 466 ,(2014) , 10.1038/NG.2950

Levi A. Garraway, Genomics-Driven Oncology: Framework for an Emerging Paradigm Journal of Clinical Oncology. ,vol. 31, pp. 1806- 1814 ,(2013) , 10.1200/JCO.2012.46.8934