Immune Response to Acute Otitis Media in Children III. Implications of Viral Antibody in Middle Ear Fluid

摘要: With the technique of radioimmunodiffusion and indirect FA staining, IgA antibody to measles, mumps, rubella, polio-1 were determined in serum middle ear fluid (MEF) 103 patients with otitis media. The occurrence viral MEF its absence simultaneously drawn was used as an indicator local production. Of 401 assays performed, 41 instances exclusively found. Only four these occurred specimens from unimmunized directed against rubella virus. 37 remaining cases, 16 each measles one, respectively, for mumps viruses. mean specific titers 8- 17-fold higher immunized individuals than persisted at least 9 19 months after immunization. data thus indicate 1) immunologic sensitization mucosa can be achieved by parenteral well oral routes immunization, 2) memory exists mucosa. These two factors are crucial feasibility immunization acute