摘要: Publisher Summary Uric acid produced in man is the product of action enzyme xanthine oxidase on and hypoxanthine. enters body as part diet but most it due to this these two purines. not only found urine serum, small amounts its precursors hypoxanthine a variety other purines are also serum urine. The chapter discusses various abnormal metabolisms purine derivatives such gout, xanthinuria, Lesch-Nyhan disease, partial phosphoribosyltransferase deficiency. Role phosphoribosyl pyrophosphate rate synthesis gout summarized. Gout excessive production uric acid, which leads deposition sodium urate parts body. extremely painful can cause serious kidney damage. An attempt has been made integrate known reactions into logical sequence steps that might explain magnitude amount suggest basis for consequences interruption. Only additional research establish extent cycle real, ultimate significance vivo.
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