How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials

摘要: Traditionally, the efficacy of cancer treatment in patients with advance or metastatic disease clinical studies has been studied using overall survival and more recently tumor-based end points such as progression-free survival, measurements response to treatment. However, these seem not be relevant current situation if were no validated surrogate demonstrate efficacy. Appropriate, meaningful, primary patient-oriented patient-reported that adequately measure effects new therapeutic interventions are then crucial for advancement research colorectal complement results points. Health-related quality life (HRQoL) is effectively an evaluation its relationship health over time. HRQoL includes patient report at least way a affects physical, emotional social well-being. Over past few years, several phase III trials variety solid cancers have assessed incremental value addition traditional tumor results. could provide only complementary data outcomes, but also precise predictive prognostic value. This point useful both clinicians order achieve dogma precision medicine. The present article examines use trials, outlines importance assessment methods, analysis, presentation. Moreover, it discusses relevance including primary/co-primary support assess advanced setting.