3D Ultrasound Measurement of Change in Carotid Plaque Volume A Tool for Rapid Evaluation of New Therapies
作者： Craig D. Ainsworth , Christopher C. Blake , Arturo Tamayo , Vadim Beletsky , Aaron Fenster
DOI: 10.1161/01.STR.0000178543.19433.20
关键词:
摘要: Background and Purpose— New therapies are being developed that antiatherosclerotic but lack intermediate end points, such as changes in plasma lipids, which can be measured to test efficacy. To study treatments, it will necessary directly measure atherosclerosis. The was designed determine sample sizes needed detect effects of treatment using 3D ultrasound (US) measurement carotid plaque. Methods— In 38 patients with stenosis >60%, age±SD 69.42±7.87 years, 15 female, randomly assigned a double-blind fashion 80 mg atorvastatin daily (n=17) versus placebo (n=21), we plaque volume at baseline after 3 months by disc segmentation voxels representing artery plaque, reconstruction parallel transverse duplex US scans into volumetric data sets. Results— There were no significant differences risk factors. rate progression 16.81±74.10 mm3 taking regression −90.25±...
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