Helicobacter pylori and its genome: lessons from the treasure map.

摘要: The availability of the complete genome sequence Helicobacter pylori 26695 has opened new avenues for research in molecular biology this gastric pathogen. present review gives a general overview H obtained from and compares with data previously cloning functional studies pylori. cagA pathogenicity island 40 kilobases, which encodes type IV secretion system, is discussed. diversity genomes well known, yet indicate that some aspects genome, particularly outer membrane protein genes, are conserved. Genes encoding proteins involved mimicry between bacterium epithelial tissue, specifically those Lewis X Y antigens, large number DNA restriction modification genes their role infection considered. Finally, gene transfer soon to be available J99 will speed up assist analysis encoded proteins. both strains useful as references other can compared.