GFRALPHA -3, A PROTEIN RELATED TO GFRALPHA -1, IS EXPRESSED IN DEVELOPING PERIPHERAL NEURONS AND ENSHEATHING CELLS

摘要: We report here the identification of a gene, termed GFRalpha-3 (glial cell line-derived neurotrophic factor family receptor alpha-3), related to GFRalpha-1 and GFRalpha-2 (also known as GDNFR-alpha GDNFR-beta), describe distribution GDNFalpha-3 in nervous system other parts mouse body during development adult. situ hybridization signals were found mainly peripheral system, with prominent developing dorsal root trigeminal ganglia. Sympathetic ganglia also positive. Developing nerves manifested strong mRNA signals, presumably generated by Schwann cells. Olfactory ensheathing cells Other non-neuronal appearing positive included chromaffin adrenal gland small clusters intestinal epithelium. In central no robust could be detected at any stage investigated present probes. Compared previously described mRNAs, which are widely distributed organs, expression is much more restricted. The suggests key role for system. As lack transducing RET receptor, we propose that possible function bind cell-derived GDNF-like ligands, thus presenting such molecules growing axons.