A Testing Framework for Identifying Susceptibility Genes in the Presence of Epistasis

摘要: An efficient testing strategy called the “focused interaction framework” (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes. In FITF approach, likelihood-ratio tests are performed stages that increase order considered. Joint main effects and conditional on significant lower-order effects. A reduction number is achieved by prescreening gene combinations with a goodness-of-fit χ2 statistic depends association among pooled group. Multiple accounted controlling false-discovery rates. Simulation analysis demonstrated approach more powerful than marginal also outperformed multifactor dimensionality when additive, dominant, or recessive an application asthma data from Children’s Health Study, identified multilocus effect between nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1), myeloperoxidase (MPO), catalase (CAT) (unadjusted P=.00026), three oxidative stress pathway. independent set consisting primarily African American Asian children, these showed status (P=.0008).