Multimodal silica-based nanoparticles
作者： Ulrich Wiesner , Andrew Burns , Jason S. Lewis , Thomas P. Quinn , Michelle S. Bradbury
DOI:
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摘要: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of disease such as cancer. has range diameters, compound positioned within the nanoparticle, greater brightness quantum yield than free compound, exhibits high biostability biocompatibility, may be coated with an organic polymer, poly( ethylene glycol) (PEG). small size silica base polymer coating minimizes toxicity when administered in vivo. further conjugated to ligand. A therapeutic agent attached nanoparticle. Further, magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions
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