Chapter 12 Molecular physiology of mammalian epithelial Na+/H+ exchangers NHE2 and NHE3
作者： Mark Donowitz , Ming Tse
DOI: 10.1016/S1063-5823(00)50014-3
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摘要: Publisher Summary This chapter discusses the molecular physiology of mammalian epithelial Na + /H exchangers (NHE)—NHE2 and NHE3. These two contribute to small intestinal, colonic, gallbladder, renal, salivary gland HCO 3 – absorption and, along with ENaC -linked substrate cotransporters, carry out most renal intestinal absorption. The provides an overview NHEs, including identified members exchanger gene family structure/function relationships NHE N terminus; cellular subcellular locations; physiological functions apical Membrane NHEs those attributed NHE2 and/or NHE3; regulation transport activity; diseases in which play a pathogenic role. NHE3 can alter intracellular pH volume. cloned isoforms are all separate genes one exception, present on different chromosomes. related NHE4 same chromosome. Pseudogenes only for All have similar membrane topology based similarity hydrophobicity predicted by multiple algorithms. also describes method used assess NHE2.
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