More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis

摘要: Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720-P). Recently, novel role FTY720 as potential anticancer drug has emerged. One the mechanisms involves induction reactive oxygen species (ROS) and subsequent apoptosis, which largely independent property an S1P modulator. ROS have been considered double-edged sword in tumor initiation/progression. Intriguingly, prooxidant therapies attracted much attention due efficacy cancer treatment. These strategies include diverse chemotherapeutic agents molecular targeted drugs such sulfasalazine inhibits CD44v-xCT (cystine transporter) axis. In this review, we introduce our recent discoveries using chemical genomics approach uncover signaling network relevant FTY720-mediated thereby proposing new targets for combination therapy means enhance antitumor generator. We extend knowledge summarizing various measures targeting vulnerability cells' defense against oxidative stress. Future directions that may lead best use ROS-targeted promising treatment are also discussed.