Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data

摘要: The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug remains a substantial concern many low and middle-income countries. Q151M T69 insertion (T69i) mutations the viral reverse transcriptase gene can reduce susceptibility all nucleoside/tide analogue inhibitors, motivating present study investigate risk factors outcomes associated with these mutations. We considered data UK HIV Drug Resistance Database for blood samples obtained period 1997–2014. Where available, treatment history patient were through linkage Collaborative Cohort study. A matched case–control approach was used assess appearance each ART-experienced patients, survival analysis suppression. further using controls performed impact mutation on survival. total 180 patients 85 T69i identified, almost entirely from before 2006. Occurrence both strongly cumulative virological failure while ART, there particular positive association use stavudine negative boosted-protease inhibitors. Subsequent suppression negatively load at sequencing mutations, we found didanosine inhibitor use. results analyses also consistent potentially large associations other drugs. Analyses inconclusive regarding between mortality, mortality high CD4 detection. are now very rare UK. Our suggest that good possible people However, this historic sample, detection important determining prognosis.