Study of flavonoids/β-cyclodextrins inclusion complexes by NMR, FT-IR, dsc, X-ray investigation

摘要: Flavonoids are natural substances with a lot of biological activities, including the antioxidant one. Their use in pharmaceutical field is, however, limited by their aqueous insolubility. As formation inclusion complexes can improve solubility water, flavonoids hesperetin, hesperidin, naringenin and naringin have been complexed β-cyclodextrin (β-CD) coprecipitation method studied solution solid state NMR, FT-IR, differential scanning calorimetry X-ray techniques. The effects complexation on chemical shifts internal external protons β-CD presence each flavonoid were observed.