Analysis of the fine specificity and cross-reactivity of monoclonal anti-lipid A antibodies.

摘要: We have investigated the fine specificity of anti-lipid A antibodies to identify conserved lipid antigens. Because derived from many different Gram-negative bacteria has similar biologic activities, regions may be particular importance for immunostimulatory and toxic properties A. found that five nine bound a wide variety bacteria. All these widely cross-reactive same antigenic site within Polymyxin B, an inhibitor activity, this as well. The native base-hydrolyzed equally well, also monosaccharide precursor X. less recognized poorly, did not recognize X at all. Other investigators shown some activities in vitro can inhibit lethal toxicity LPS vivo. On basis study, we suggest contains epitope