Venovenous hemodiafiltration for patient with baclofen intoxication

摘要: Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose 1,850 mg at the first episode and up 2,500 second. In both cases patient had severe overdose symptoms scored 4-5 on Glascow Coma Scale intensive care. Continuous venovenous hemodiafiltration (CVVHDF) initiated. elimination pharmacokinetics toxicokinetics for is not fully known. During second submission shorter half-life time observed it might be due either compartmental distribution of baclofen, or more likely caused an advantageous effect CVVHDF.