Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer
作者： Qi Niu , Xiyuan Yu , Qinling Yuan , Weijie Hu , Dongsheng Yu
DOI: 10.1016/J.CPLETT.2019.136977
关键词:
摘要: Abstract The lysine-proline-valine tripeptide (KPV) can transport into colorectal cancer (CRC) cells via oligopeptide transporter 1 (PepT1) selectively. Here, we successfully designed a fluorescent probe for PepT1 receptor-targeted CRC imaging. This consisted of the CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) conjugated with KPV (QD-PAAO-KPV), exhibiting excellent near-infrared emission characteristics. in vitro and vivo results showed that QD-PAAO-KPV was specifically efficiently internalized PepT1-overexpressing Caco-2 tumor. In addition, it demonstrated possessed good biological activities. Thus, this study revealed presented desirable targeting ability, showing promising prospects detection.
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