Strategies for Management of Prostate Cancer-Related Bone Pain

摘要: Prostate cancer is one of the most common malignancies and a leading cause cancer-related death in men worldwide. In majority cases, prostate metastasises to skeleton, which case bone pain becomes major morbidity. Androgen ablation treatment choice for securing regression skeletal metastases cases. Intermittent androgen an attractive alternative, aimed at minimising adverse effects hormone deprivation but also potentially delaying hormone-refractoriness. The development hormone-refractoriness heralded by significant increase morbidity largely because escalating caused progression metastatic process. Skilful use analgesics initially successful eventually fails control symptoms. Localised are best treated with local radiotherapy that rapidly effective. Over last few years, it has become clear therapeutic modalities using bone-seeking radionuclides or bisphosphonates have been effective palliation pain, although not affecting survival. main limiting factor marrow suppression, feature very late stages cancer. Bisphosphonates do carry this disadvantage. Results large double-blind, placebo-controlled studies should be awaited, however, before advocating widespread these agents management patients metastases.