Role of Alpha‐Tocopherol, Ascorbic Acid, Citric Acidand EDTA as Oxidants in Model Systems
作者： JOHN R. MAHONEY , ERNST GRAF
DOI: 10.1111/J.1365-2621.1986.TB13108.X
关键词:
摘要: The effects of four widely employed “antioxidants” on iron-mediated hydroxyl radical formation and lipid peroxidation were studied in aqueous model systems. Iron copper served as catalysts for the reactions which oxidized ascorbic acid alpha-tocopherol reduced oxygen. Ferrous ion spontaneously oxygen to O−2 (su-peroxide anion radical) led OH (hydroxyl H2O2 generation peroxidation. Precipitation or sequestration iron greatly depressed these oxidative events. Complexation by EDTA citric acid, however, formed catalytically active chelates. concomitant increase solubility explained substantial enhancement iron-driven redox acid.
sci-hub.se 参考文章(9)
E Graf, J R Mahoney, R G Bryant, J W Eaton, Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. Journal of Biological Chemistry. ,vol. 259, pp. 3620- 3624 ,(1984) , 10.1016/S0021-9258(17)43139-5
John A. Buege, Steven D. Aust, Microsomal lipid peroxidation. Methods in Enzymology. ,vol. 52, pp. 302- 310 ,(1978) , 10.1016/S0076-6879(78)52032-6
T. Nash, The colorimetric estimation of formaldehyde by means of the Hantzsch reaction Biochemical Journal. ,vol. 55, pp. 416- 421 ,(1953) , 10.1042/BJ0550416
B Halliwell, J M C Gutteridge, OXYGEN TOXICITY, OXYGEN RADICALS, TRANSITION METALS AND DISEASE Biochemical Journal. ,vol. 219, pp. 1- 14 ,(1984) , 10.1042/BJ2190001
JOSEPH KANNER, HAVA MENDEL, PIERRE BUDOWSKI, PROOXIDANT AND ANTIOXIDANT EFFECTS OF ASCORBIC ACID AND METAL SALTS IN A β‐CAROTENE‐LINOLEATE MODEL SYSTEM Journal of Food Science. ,vol. 42, pp. 60- 64 ,(1977) , 10.1111/J.1365-2621.1977.TB01218.X
J. Cillard, P. Cillard, M. Cormier, L. Girre, α-Tocopherol prooxidant effect in aqueous media: Increased autoxidation rate of linoleic acid Journal of the American Oil Chemists' Society. ,vol. 57, pp. 252- 255 ,(1980) , 10.1007/BF02668254
J. P. Koskas, J. Cillard, P. Cillard, Autoxidation of linoleic acid and behavior of its hydroperoxides with and without tocopherols Journal of the American Oil Chemists' Society. ,vol. 61, pp. 1466- 1469 ,(1984) , 10.1007/BF02636367
Cheves Walling, Fenton's reagent revisited Accounts of Chemical Research. ,vol. 8, pp. 125- 131 ,(1975) , 10.1021/AR50088A003
Martell A E, Chelates of ascorbic acid. Formation and catalytic properties. Advances in chemistry series. pp. 153- 178 ,(1982)