T1 Signal Measurements in Pediatric Brain: Findings after Multiple Exposures to Gadobenate Dimeglumine for Imaging of Nonneurologic Disease.

摘要: BACKGROUND AND PURPOSE: Signal intensity increases possibly suggestive of gadolinium retention have recently been reported on unenhanced T1-weighted images the pediatric brain following multiple exposures to gadolinium-based MR contrast agents. Our aim was determine whether T1 signal changes deposition occur in brains nonneurologic patients after gadobenate dimeglumine. MATERIALS METHODS: Thirty-four (group 1; 17 males/17 females; mean age, 7.18 years) who received between 5 and 15 injections (mean, 7.8 injections) 0.05 mmol/kg during a 2.24 years were compared with 24 control 2; 16 males/8 8.78 had never Exposure for diagnosis therapy monitoring. Five blinded readers independently determined at ROIs dentate nucleus, globus pallidus, pons, thalamus spin-echo from both groups. Unpaired t tests used compare signal-intensity values nucleus–pons pallidus–thalamus ratios groups 1 2. RESULTS: Mean gadobenate-exposed ranged 366.4 389.2, 360.5 392.9, 370.5 374.9, 356.9 371.0, respectively. Corresponding agent–naive subjects not significantly different ( P > .05). Similarly, no significant differences noted by any reader comparisons ratios. One difference (1.06 ± 0.006 versus 1.02 0.009, = .002), but this reflected nonsignificantly higher subjects. The number interval first last did influence values. CONCLUSIONS: Signal-intensity potentially indicative are seen low-dose gadobenate.