In-vivo behaviour of hypodermically implanted microfabricated glucose sensors.
作者： M. Koudelka , F. Rohner-Jeanrenaud , J. Terrettaz , E. Bobbioni-Harsch , N.F. de Rooij
DOI: 10.1016/0956-5663(91)85005-H
关键词:
摘要: The in-vivo behaviour of microfabricated GOD (glucose oxidase)/ H2O2 glucose sensor implanted subcutaneously in normal anesthetized rats has been studied. consists a planar, three-electrode microcell, an enzyme membrane oxidase and bovine serum albumin cross-linked with glutaraldehyde) outer diffusion limiting polyurethane membrane. during hyperglycaemic (13.8 mM 11.2 mM), euglycaemic (7.8 mM) hypoglycaemic (3.5 plateau levels was determined. values the sensitivity (0.64 \xb1 0.05 nA/mM) background current (1.25 0.4 nA) were determined using two- point calibration method then used to calculate apparent subcutaneous concentrations. results show presence good correlation between all plasma (G) tissue concentrations (G'), G' = 0.997 . G - 0.066. r 0.9782.
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sci-hub.se 参考文章(14)
K. Rebrin, U. Fischer, T.v. Woedtke, P. Abel, E. Brunstein, Automated feedback control of subcutaneous glucose concentration in diabetic dogs. Diabetologia. ,vol. 32, pp. 573- 576 ,(1989) , 10.1007/BF00285330
D. J. Claremont, E. Sambrook, C. Penton, J. C. Pickup, Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs. Diabetologia. ,vol. 29, pp. 817- 821 ,(1986) , 10.1007/BF00873223
M. Shichiri, R. Kawamori, Y. Goriya, Y. Yamasaki, M. Nomura, N. Hakui, H. Abe, Glycaemic control in pancreatectomized dogs with a wearable artificial endocrine pancreas. Diabetologia. ,vol. 24, pp. 179- 184 ,(1983) , 10.1007/BF00250158
M. Koudelka, S. Gernet, N.F. De Rooij, Planar Amperometric Enzyme-Based Glucose Microelectrode Sensors and Actuators. ,vol. 18, pp. 157- 165 ,(1989) , 10.1016/0250-6874(89)87015-5
S. Ertefai, D.A. Gough, Physiological preparation for studying the response of subcutaneously implanted glucose and oxygen sensors. Journal of Biomedical Engineering. ,vol. 11, pp. 362- 368 ,(1989) , 10.1016/0141-5425(89)90097-6
M. Shichiri, N. Asakawa, Y. Yamasaki, R. Kawamori, H. Abe, Telemetry Glucose Monitoring Device With Needle-Type Glucose Sensor: A Useful Tool for Blood Glucose Monitoring in Diabetic Individuals Diabetes Care. ,vol. 9, pp. 298- 301 ,(1986) , 10.2337/DIACARE.9.3.298
D. R. Matthews, E. Bown, T. W. Beck, E. Plotkin, L. Lock, E. Gosden, M. Wickham, An amperometric needle-type glucose sensor tested in rats and man. Diabetic Medicine. ,vol. 5, pp. 248- 252 ,(1988) , 10.1111/J.1464-5491.1988.TB00978.X
U. Fischer, R. Ertle, P. Abel, K. Rebrin, E. Brunstein, H. Hahn von Dorsche, E. J. Freyse, Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs Diabetologia. ,vol. 30, pp. 940- 945 ,(1987) , 10.1007/BF00295878
J. C. Pickup, G. W. Shaw, D. J. Claremont, In vivo molecular sensing in diabetes mellitus: an implantable glucose sensor with direct electron transfer Diabetologia. ,vol. 32, pp. 213- 217 ,(1989) , 10.1007/BF00265097
S. Gernet, M. Koudelka, N.F. De Rooij, Fabrication and characterization of a planar electrochemical cell and its application as a glucose sensor Sensors and Actuators. ,vol. 18, pp. 59- 70 ,(1989) , 10.1016/0250-6874(89)87025-8