Involvement of neuronal nitric oxide synthase in cognitive impairment in isoflurane-treated rats.
作者： Xue-Bin Yan , Wen Ouyang , Guan Li , Kai-Ming Duan
DOI: 10.1016/J.NEULET.2011.11.015
关键词:
摘要: The underlying causes of post-operative cognitive dysfunction (POCD) in elderly patients remain to be elucidated. In order explore possible contributory mechanisms, we tested the effects isoflurane anesthesia on (i) expression hippocampal neuronal nitric oxide synthase (nNOS) and (ii) relationship changes nNOS isoflurane-treated aged rats. Our results indicate that treatment leads significant correct reactions (F=28.35, p<0.001), initiative avoidances (F=29.33, total reaction time (TRT) (F=6.99, p<0.05) treated rats Y-maze test. Isoflurane-treated had fewer test 24 48 h after 2 compared with control group (p<0.05). TRTs complete 20 trials increased significantly anesthesia. number nNOS-positive neurons decreased anesthesia, corresponding an mean immunostaining grey-scale value. These data show a transient decrease during early post-anesthesia stages, is closely correlated impairment
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